In animal studies, taurine caused muscles to work harder and for … View abstract. 1996;150(3):284-288. View abstract. J Abnorm Child Psychol 1979;7:145-51.. View abstract. Caffeine intake during pregnancy and adverse birth outcomes: a systematic review and dose-response meta-analysis. Ascherio A, Zhang SM, Hernan MA, et al. View abstract. Cancer Lett. View abstract. Gant, N., Ali, A., and Foskett, A. 2010;11:49. Tension headache. Leitzmann MF, Willett WC, Rimm EB, et al. Caffeine is a commonly consumed psychoactive drug which produces its psychomotor stimulant and reinforcing effects through antagonism at adenosine receptors and indirect effects on dopaminergic neurotransmission.1 Consumption of caffeine at recommended dietary doses is not generally associated with negative health consequences,2 and caffeine has some clinical utility, such as for enhancement of analgesia.3 However, there is also evidence that some caffeine consumers might experience caffeine-r… A double-blind crossover study. Jiang X, Zhang D, Jiang W. Coffee and caffeine intake and incidence of type 2 diabetes mellitus: a meta-analysis of prospective studies. J Sports Sci. Smillie, L. D. and Gokcen, E. Caffeine enhances working memory for extraverts. View abstract. Consult with your health care provider for additional questions or concerns about the use of caffeine. View abstract. BMC Med. Epilepsia 2010;51(2):198-205. Cochrane.Database.Syst.Rev. Center for the Evaluation of Risks to Human Reproduction (CERHR). Lopez-Garcia, E., Rodriguez-Artalejo, F., Rexrode, K. M., Logroscino, G., Hu, F. B., and van Dam, R. M. Coffee consumption and risk of stroke in women. A., Perault, M. C., Enslen, M., Chauffard, F., Vandel, B., and Tachon, P. The effects of 600 mg of slow release caffeine on mood and alertness. View abstract. Forensic Sci Med Pathol. J Am Heart Assoc. View abstract. Am J Clin Nutr 2004;79:40-6. Withdrawal of caffeine, even from moderate intake levels, can produce symptoms such as headache, fatigue and anxiety. Bara AI, Barley EA. View abstract. View abstract. Inhibition of caffeine metabolism by estrogen replacement therapy in postmenopausal women. Association of coffee consumption with gallbladder disease. View abstract. Tunnicliffe, J. M., Erdman, K. A., Reimer, R. A., Lun, V., and Shearer, J. View abstract. View abstract. Low levels of oxygen in the blood caused by exercise. 2011 August. View abstract. Curr.Med.Res.Opin. View abstract. The body breaks down caffeine to get rid of it. For example, about 2.73 milligrams of caffeine (from anhydrous), per 1 pound of bodyweight (or, about 491 milligrams of caffeine for a 180-pound adult), consumed one hour prior to a cycling test to exhaustion was shown to improve the time to exhaustion by about 23 percent and slightly increased the use of fat as fuel, to the tune of about 3 percent. Epub 2014 2. View abstract. Lv, X., Chen, Z., Li, J., Zhang, L., Liu, H., Huang, C., and Zhu, P. Caffeine protects against alcoholic liver injury by attenuating inflammatory response and oxidative stress. View abstract. View abstract. It is also added to drinks, food, supplements, medicines, and herbal products. Biol Psychol. J Caffeine Res 2011;1(3):179-185. Artin, B., Singh, M., Richeh, C., Jawad, E., Arora, R., and Khosla, S. Caffeine-related atrial fibrillation. Ergonomics 1989;32(10):1193-1205. View abstract. Nutrients. View abstract. Infante S, Baeza ML, Calvo M, et al. Welborn, L. G., Hannallah, R. S., Fink, R., Ruttimann, U. E., and Hicks, J. M. High-dose caffeine suppresses postoperative apnea in former preterm infants. Ann.Emerg.Med. Clin Pharmacol Ther 1993;54(2):194-204. Caldeira D, Martins C, Alves LB, Pereira H, Ferreira JJ, Costa J. Caffeine does not increase the risk of atrial fibrillation: a systematic review and meta-analysis of observational studies. B., and Dishman, R. K. Acute exercise reduces caffeine-induced anxiogenesis. Birth control pills can decrease how quickly the body breaks down caffeine. View abstract. View abstract. Am.J.Clin.Nutr. This also includes any herbal, dietary, or prescription medications that contain caffeine. A., and Leino, T. K. Effect of caffeine on simulator flight performance in sleep-deprived military pilot students. View abstract. 1987;42(6):621-626. 2018 Apr 26. 2012;95(4):901-908. Very premature infants have trouble breathing on their own. But it is dangerous and one may collapse if not consumes it under certain limit. van Gelder, B. M., Buijsse, B., Tijhuis, M., Kalmijn, S., Giampaoli, S., Nissinen, A., and Kromhout, D. Coffee consumption is inversely associated with cognitive decline in elderly European men: the FINE Study. View abstract. Available at: https://books.nap.edu/books/0309082587/html/index.html. Xu, Y. and Venton, B. J. doi: 10.1016/j.ajem.2013.08.042. Wnuk, M., Lewinska, A., Oklejewicz, B., Bugno, M., Slota, E., and Bartosz, G. Evaluation of the cyto- and genotoxic activity of yerba mate (Ilex paraguariensis) in human lymphocytes in vitro. Pharmacotherapy 2001;21:647-51.. View abstract. View abstract. The positive effects that have been described in people who use caffeine include improved motor performance, decreased fatigue, enhanced sensory activity, and increased alertness. Li, G. Z., Zhang, N., Du, P., Yang, Y., Wu, S. L., Xiao, Y. X., Jin, R., Liu, L., Shen, H., and Dai, Y. J Sleep Res. 2018;28(12):1261-1266. Shechter, M., Shalmon, G., Scheinowitz, M., Koren-Morag, N., Feinberg, M. S., Harats, D., Sela, B. J Sleep Res 2008;17(3):309-321. J Pediatr 2010;156(3):382-387. View abstract. Lloyd T, Johnson-Rollings N, Eggli DF, et al. 9-1-2002;156(5):445-453. View abstract. Ruusunen, A., Lehto, S. M., Tolmunen, T., Mursu, J., Kaplan, G. A., and Voutilainen, S. Coffee, tea and caffeine intake and the risk of severe depression in middle-aged Finnish men: the Kuopio Ischaemic Heart Disease Risk Factor Study. View abstract. View abstract. Metabolism 2007;56(12):1694-1698. Last updated on May 28, 2020. Fraumeni, J. F., Jr., Scotto, J., and Dunham, L. J. Coffee-drinking and bladder cancer. Neurology 8-7-2007;69(6):536-545. View abstract. J Sports Sci 2009;27(6):661-666. View abstract. Chin Med J (Engl.) Conlisk, A. J. and Galuska, D. A. N Engl J Med 1999;341:1688-9. May Boost Exercise Performance. No association between coffee consumption and adverse outcomes of pregnancy. Kumral, A., Yesilirmak, D. C., Aykan, S., Genc, S., Tugyan, K., Cilaker, S., Akhisaroglu, M., Aksu, I., Sutcuoglu, S., Yilmaz, O., Duman, N., and Ozkan, H. Protective effects of methylxanthines on hypoxia-induced apoptotic neurodegeneration and long-term cognitive functions in the developing rat brain. Goto, A., Song, Y., Chen, B. H., Manson, J. E., Buring, J. E., and Liu, S. Coffee and caffeine consumption in relation to sex hormone-binding globulin and risk of type 2 diabetes in postmenopausal women. 2019;271:732-739. Quirce, G. S., Freire, P., Fernandez, R. M., Davila, I., and Losada, E. Urticaria from caffeine. View abstract. Anderson, M. E., Bruce, C. R., Fraser, S. F., Stepto, N. K., Klein, R., Hopkins, W. G., and Hawley, J. Europace 2016 Feb;18(2):257-66. Br J Clin Pharmacol 2000;49:59-63. Am.J Respir.Crit Care Med. View abstract. View abstract. Uses of Caffeine: 1.In medicine, it is used to stimulate, central nervous system and to increase flow of urine. Stille, W., Harder, S., Mieke, S., Beer, C., Shah, P. M., Frech, K., and Staib, A. H. Decrease of caffeine elimination in man during co-administration of 4-quinolones. View abstract. Lancet 11-27-1971;2(7735):1204. Bruce, C. R., Anderson, M. E., Fraser, S. F., Stepto, N. K., Klein, R., Hopkins, W. G., and Hawley, J. J Headache Pain 2010;11(4):349-354. Chem.Pharm Bull (Tokyo) 2009;57(11):1284-1288. Durlach PJ. Lack of pharmacological active saliva levels of caffeine in breast-fed infants. Chemically known as 1,3,7-trimethylxanthine, caffeine is also used in sports drinks, weight loss supplements. J Invest Dermatol. Biol.Psychol. Mol.Cancer Ther. But caffeine doesn't seem to improve performance during short-term, high-intensity exercise such as sprinting and certain types of lifting. Am.J Vet.Res. View abstract. Effects of oral caffeine on postdural puncture headache. Association of coffee and caffeine intake with the risk of parkinson disease. Med Sci Sports Exerc. Medications for depression (MAOIs) interacts with CAFFEINE. View abstract. Iranpour S, Sabour S. Inverse association between caffeine intake and depressive symptoms in US adults: data from National Health and Nutrition Examination Survey (NHANES) 2005-2006. 24h withdrawal following repeated administration of caffeine attenuates brain serotonin but not tryptophan in rat brain: implications for caffeine-induced depression. J Sports Sci. View abstract. View abstract. 2007;64(11):965-967. Bryant, C. M., Dowell, C. J., and Fairbrother, G. Caffeine reduction education to improve urinary symptoms. Woolf, K., Bidwell, W. K., and Carlson, A. G. The effect of caffeine as an ergogenic aid in anaerobic exercise. Adenosine (Adenocard) interacts with CAFFEINE. Leg pain during exercise due to poor blood flow (intermittent claudication). Caffeine citrate for the treatment of apnea of prematurity: a double-blind, placebo-controlled study. View abstract. Total, caffeinated and decaffeinated coffee and tea intake and gastric cancer risk: results from the EPIC cohort study. Ergenekon E, Dalgic N, Aksoy E, et al. Porkka-Heiskanen, T. Methylxanthines and sleep. View abstract. Paediatr.Respir.Rev. View abstract. Pimentel, G. D., Zemdegs, J. C., Theodoro, J. Diabetes medications are used to lower blood sugar. View abstract. Knight, J. M., Avery, E. F., Janssen, I., and Powell, L. H. Cortisol and depressive symptoms in a population-based cohort of midlife women. Eur.J Appl.Physiol 2011;111(6):1135-1146. View abstract. View abstract. 2018;4(4):425-32. View abstract. View abstract. However, there can be unwanted side effects. Int J Sport Nutr Exerc.Metab 2009;19(4):410-423. Am J Epidemiol. Schmitt, J. Ozkan, B., Yuksel, N., Anik, Y., Altintas, O., Demirci, A., and Caglar, Y. Effect of caffeine supplementation on repeated sprint running performance. Br.J Nutr 2010;103(3):453-459. View abstract. Association of fractures with caffeine and alcohol in postmenopausal women: the Iowa Women's Health Study. Cephalalgia 2005;25(10):776-787. 2014 Jun;49:39-43. doi: 10.1016/j.jsr.2014.02.006. 2.Because of its stimulating effects, caffeine has been used to relieve fatigue. Psychopharmacology (Berl) 2011;214(3):737-745. Risk factors associated with short sleep duration among Chinese school-aged children. Ker, K., Edwards, P. J., Felix, L. M., Blackhall, K., and Roberts, I. Caffeine for the prevention of injuries and errors in shift workers. View abstract. Check with your health care provider before you start, stop, or change the dose of any medicine. 2012;62(7):2320-7. doi: 10.1016/j.neuropharm.2012.01.020. Habitual caffeine intake and the risk of hypertension in women. Szpak A, Allen D. A case of acute suicidality following excessive caffeine intake. Am J Epidemiol 1996:144:642-4. N.Engl.J Med 7-17-1980;303(3):122-124. 2016 Oct 14;8(10). Hurley CF, Hatfield DL, Riebe DA. Chroscinska-Krawczyk, M., Jargiello-Baszak, M., Walek, M., Tylus, B., and Czuczwar, S. J. Caffeine and the anticonvulsant potency of antiepileptic drugs: experimental and clinical data. Caffeine citrate is more commonly used for medical purposes rather than supplementation. Effects of habitual caffeine use and acute ingestion: testing a biobehavioral model. Some athletes use caffeine to improve their performance in sports activities. Call your health care provider for medical advice about side effects. 2013;43(3):161-9. doi: 10.1016/j.neucli.2013.04.001. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Migraine. Int.J.Sport Nutr.Exerc.Metab 2002;12(4):438-452. Shirlow, M. J. and Mathers, C. D. A study of caffeine consumption and symptoms; indigestion, palpitations, tremor, headache and insomnia. View abstract. Can J Psychiatry 2001;46:454-5. View abstract. The Various Uses of Caffeine. Aranda, J. V., Gorman, W., Bergsteinsson, H., and Gunn, T. Efficacy of caffeine in treatment of apnea in the low-birth-weight infant. Birth control pills (Contraceptive drugs) interacts with CAFFEINE. Boyett JC, Giersch GE, Womack CJ, et al. Dews PB, O'Brien CP, Bergman J. Caffeine: behavioral effects of withdrawal and related issues. Julien, C. A., Joseph, V., and Bairam, A. Caffeine reduces apnea frequency and enhances ventilatory long-term facilitation in rat pups raised in chronic intermittent hypoxia. View abstract. Indian J Med Res 2010;132:36-41. Hagg S, Spigset O, Mjorndal T, Dahlqvist R. Effect of caffeine on clozapine pharmacokinetics in healthy volunteers. 2018 May 14;10(5). J.Nutr.Health Aging 2003;7(5):301-303. View abstract. JAMA Pediatr. Brouard, C., Moriette, G., Murat, I., Flouvat, B., Pajot, N., Walti, H., de Gamarra, E., and Relier, J. P. Comparative efficacy of theophylline and caffeine in the treatment of idiopathic apnea in premature infants. J Alzheimers.Dis. J Alzheimers.Dis. Epub 2012 2. View abstract. View abstract. Henderson-Smart, D. J. and De Paoli, A. G. Prophylactic methylxanthine for prevention of apnoea in preterm infants. Whitsett, T. L., Manion, C. V., and Christensen, H. D. Cardiovascular effects of coffee and caffeine. Int J Neurosci. Gray, P. H., Flenady, V. J., Charles, B. G., and Steer, P. A. Caffeine citrate for very preterm infants: Effects on development, temperament and behaviour. View abstract. View abstract. View abstract. View abstract. Eur J Clin Pharmacol 2000;56:537-44.. View abstract. Stookey JD. Limitations of theophylline in the treatment of apnea of prematurity. J Pain Symptom Manage. View abstract. Is caffeine a cognitive enhancer? Do not double-up on your caffeine dose if you should miss the time for next dose. View abstract. Behav Brain Res 12-20-2010;215(1):39-44. Clin.Pharmacol.Ther. Recent advances on Ilex paraguariensis research: Minireview. Moderate to heavy caffeine consumption during pregnancy and relationship to spontaneous abortion and abnormal fetal growth: a meta-analysis. Am J Clin Nutr 1999;70:1040-5. View abstract. View abstract. Anaesth Intensive Care 1999;27:307-11. Medically reviewed by Philip Thornton, DipPharm. View abstract. Epub 2013 31. J Strength Cond Res. Robinson, L. E., Spafford, C., Graham, T. E., and Smith, G. N. Acute caffeine ingestion and glucose tolerance in women with or without gestational diabetes mellitus. Dreher HM. 1999;9(4):361-370. University of Bristol, School of Chemistry Web Site. Stuart, G. R., Hopkins, W. G., Cook, C., and Cairns, S. P. Multiple effects of caffeine on simulated high-intensity team-sport performance. Ferre, S., Popoli, P., Gimenez-Llort, L., Rimondini, R., Muller, C. E., Stromberg, I., Ogren, S. O., and Fuxe, K. Adenosine/dopamine interaction: implications for the treatment of Parkinson's disease. View abstract. Epub 2012 Aug 1. FitzSimmons, C. R. and Kidner, N. Caffeine toxicity in a bodybuilder. Chen, X., Ghribi, O., and Geiger, J. D. Caffeine protects against disruptions of the blood-brain barrier in animal models of Alzheimer's and Parkinson's diseases. Psychopharmacology (Berl). Biggs, S. N., Smith, A., Dorrian, J., Reid, K., Dawson, D., van den Heuvel, C., and Baulk, S. Perception of simulated driving performance after sleep restriction and caffeine. 2017 Apr;95(4):455-458. FDA takes step to protect consumers against dietary supplements containing dangerously high levels of extremely concentrated or pure caffeine. Seek medical attention right away if any of these severe side effects occur: This is not a complete list of all side effects that may occur. Ernest, D., Chia, M., and Corallo, C. E. Profound hypokalaemia due to Nurofen Plus and Red Bull misuse. Effects of caffeinated coffee consumption on intraocular pressure, ocular perfusion pressure, and ocular pulse amplitude: a randomized controlled trial. Xu, K., Xu, Y. H., Chen, J. F., and Schwarzschild, M. A. Neuroprotection by caffeine: time course and role of its metabolites in the MPTP model of Parkinson's disease. A case of caffeine-induced coronary artery vasospasm of a 17-year-old male. View abstract. J.Urol. View abstract. View abstract. Available at: https://cerhr.niehs.nih.gov/common/caffeine.html. Int.J.Clin.Pharmacol.Ther.Toxicol. Epub 2012 30. Caraballo PJ, Heit JA, Atkinson EJ, et al. Neurology 11-2-2010;75(18):1583-1588. Systematic review of the potential adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. View abstract. ):57-64 the action of adenosine ( Adenocard ) is often used by doctors to do a on. 111 ( 6 ):573-577 kivity, S. W. the effect of.... 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